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I will start tx soon and would like some input as to the best time to take meds, injection once a week and oral meds every 8 hours. 1/5 ( 61 votes) You can take Januvia in the morning or at night, but it's best to get into a routine of taking it at the same time each day. 1/5 ( 61 votes) You can take Januvia in the morning or at night, but it's best to get into a routine of taking it at the same time each day. I will start tx soon and would like some input as to the best time to take meds, injection once a week and oral meds every 8 hours. I will start tx soon and would like some input as to the best time to take meds, injection once a week and oral meds every 8 hours. The effect of Januvia (generic name: sitagliptin) on your blood sugar levels may begin quickly, within the first 1 to 2 weeks. The effect of Januvia (generic name: sitagliptin) on your blood sugar levels may begin quickly, within the first 1 to 2 weeks. 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